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48 , 49 Further, studies have shown that there are significant changes in the heart rate such as tachycardia and increased heart rate variability.

Values in the parenthesis are the specificity and sensitivity of the panel.
In the original study, it showed a better performance when compared to the others.
Looking at the temporal properties of the dataset, seizures in patients tend to show a pattern in relation to the time.

TBI, traumatic brain injury; CT, computerized tomography; AUC, area under the curve; CI, confidence interval. CT, computerized tomography; TBI, traumatic brain injury; tSAH, traumatic subarachnoid hemorrhage. The distribution of preictal, ictal, and interictal class in the datasets. JP, RT, AK, MM, IH, H-RM, JT, PK, and OT collected and curated the data. JP drafted the manuscript with critical contributions from RT, RR, and TL.

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Traumatic brain injury (TBI) is a highly heterogeneous disease (1) and a leading cause of long-term disability globally (2).
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JP has received a speaker’s fee from the Finnish Medical Association. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor is currently organizing a Research Topic with some of the authors OT and J-CS.

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Regarding the temporal properties of EEG datasets, the length of segments varies across all datasets for both continuous and noncontinuous datasets as shown in Table 8. Within the same dataset itself, the length of each segment is different where each seizure event can be divided into multiple ictal or preictal segments. This can be seen in Table 8, where the Helsinki University Hospital EEG dataset has a median epoch length of 74 minutes, and the Neurovista ictal dataset has different seizure segment lengths, with an average of 107 seconds.

Table 4

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Number of channels, placement method of the channels, and type of signal for the datasets.
Finally, we aggregated all EEG seizure datasets found from our systematic data search and removed any private or nonaccessible EEG datasets for our analysis.
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The lower limits of detection, the lower limits of quantification, and the calibration ranges for the blood-based biomarkers are shown in Supplementary Table 1.

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The Neurovista ictal dataset, which only includes ictal events, has a total of 2979 segments.
Datasets that contain at least 24 hours of data for some patients such as CHB‐MIT allow a seizure detection and prediction model, which considers the time component in their algorithm.
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The number of channels in the Siena Scalp EEG dataset is 29, with the exception of one subject who has a 20‐channel EEG recording.
The clinical data evaluated were sex, age, GCS, assessment of pupil response, and presence of hypoxia, hypotension, and hemoglobin values also referring to the admission to the service.

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, 47 ML models with natural language processing components might be able to interpret medical records of each patient to better tune the model to detect or predict patient‐specific seizures. Using EMG‐based seizure detection devices attached on specific body parts such as the arms, studies have demonstrated the ability to detect generalized tonic–clonic seizures (GTCS) to detect seizures with sensitivities of more than 90%.

The biomarker levels in different outcome groups are presented in Supplementary Tables 4, 5. [newline]Blood samples for plasma Aβ40, Aβ42, GFAP, H-FABP, IL-10, NF-L, S100B, and t-tau were drawn within 24 h from admission.
Furthermore, datasets like Kaggle UPenn and TUSZ have a varying number of channels among their subjects with huge amounts of variation.
Within the same dataset itself, the length of each segment is different where each seizure event can be divided into multiple ictal or preictal segments.
The dataset that contains the largest number of subjects is TUSZ with 592, followed by the Helsinki University Hospital and CHB‐MIT datasets with 79 and 23 subjects, respectively.
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The only dataset that applied band filtering of between 0.5 and 70 Hz was the Hauz Khas dataset. Each of the segments in TUSZ is pruned to reduce the length of each segment to less than an hour. Noncontinuous datasets generally come with random segmentation, where there are no time relationships between each of the neighboring segments. Noncontinuous datasets that are randomly segmented, such as the University of Bonn, Hauz Khas, and Kaggle datasets, are chosen from the unpublished continuous dataset based on multiple criteria depending on the classification tasks.

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However, scientists and physicians need to get note that datasets that follow the similar electrode positioning method might nevertheless have a various quantity of channels along with additional electrodes or even channels to boost EEG resolutions.
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We hypothesized that the prognostic performance of the HCTS would improve after adding blood-based biomarkers.
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TUSZ has the highest number of seizure events at 3050, followed by The Kaggle competition dataset from Melbourne University and Helsinki University Hospital EEG at 633 and 460 seizure events, respectively.
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The Kaggle UPenn and Siena Scalp EEG datasets have the lowest seizure events recorded at 48 and 47, respectively.
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Most modern TBI biomarker studies have investigated the individual prediction abilities of different molecules.
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All authors substantially contributed to the revision of the manuscript.

However, the noncontinuous Hauz Khas dataset contains preictal, ictal, and interictal events, allowing for its use for both tasks. On the other hand, the remaining continuous datasets are more flexible, since the recordings capture preictal, ictal, and interictal events. Table 4 also shows the main application that is suitable for the use of the datasets. Admission levels of IL-10 and Aβ40 improve the prognostic performance of the HCTS in discriminating patients with unfavorable and favorable outcomes. When studied alone, HCTS had the highest pAUCs of the tested covariates, followed by Aβ40 and Aβ42. Although the individual specificities of the HCTS and biomarkers remained low (2–33%) in isolation, the optimal combination panel yielded a specificity of 59% when the sensitivity was set above 90%.

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Hence, studies that intend to produce algorithms that are patient‐specific, identifying patient‐specific biomarkers, should avoid the University of Bonn and Hauz Khas datasets. The dataset that contains the largest number of subjects is TUSZ with 592, followed by the Helsinki University Hospital and CHB‐MIT datasets with 79 and 23 subjects, respectively. The TUSZ corpus contains the most variation in terms of EEG characteristics in the recordings. While most recordings obtained originated from human subjects, datasets from Kaggle competitions such as Kaggle UPenn and American Epilepsy Society contain EEG recordings of both human and canine subjects. We adapted the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) guidelines to perform a data search as shown in Figure 1. The search of relevant literature that used an EEG seizure dataset was divided into two parts.

The AUC, demonstrated in Figure 1, confirms the best prediction of the Rotterdam and Helsinki CT scores regarding the Marshall CT class, which presented greater discriminative ability. These two models also presented better calibration, demonstrated by higher Brier Score values (Table 3). Where chemical depends on the particular dataset itself, while b and farrenheit are determined by the particular authors of the research.